Intestinal Alkaline Phosphatase Protein (ALPI) (Fc Tag)
Quick Overview for Intestinal Alkaline Phosphatase Protein (ALPI) (Fc Tag) (ABIN7317284)
Target
See all Intestinal Alkaline Phosphatase (ALPI) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Purification tag / Conjugate
- This Intestinal Alkaline Phosphatase protein is labelled with Fc Tag.
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Purpose
- Recombinant Human Alkaline Phosphatase/ALPI Protein (Fc Tag)(Active)
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Sequence
- Met 1-Asp 503
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Characteristics
- A DNA sequence encoding the mature form of human ALPI (P09923) (Met 1-Asp 503),without the pro peptide, was fused with a polyhistidine tag at the C-terminus.
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Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Measured by its ability to cleave a fluorogenic substrate, 4-Methylumbelliferyl phosphate (4-MUP).The specific activity is > 10,000 pmoles/min/μg.
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Intestinal Alkaline Phosphatase (ALPI) (AA 1-557) protein (His tag)
custom-made ALPI Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Intestinal Alkaline Phosphatase (ALPI) (AA 74-162) protein (GST tag)ALPI Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Intestinal Alkaline Phosphatase (ALPI) protein (Myc-DYKDDDDK Tag)ALPI Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from sterile PBS, pH 7.4
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Intestinal Alkaline Phosphatase (ALPI)
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Alternative Name
- Alkaline Phosphatase/ALPI
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Background
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Background: Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.
Synonym: IAP
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Molecular Weight
- 79.5 kDa
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UniProt
- P09923
Target
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