IDH1 Protein (R132H) (His tag)
Quick Overview for IDH1 Protein (R132H) (His tag) (ABIN7318691)
Target
See all IDH1 ProteinsProtein Type
Origin
Source
Purity
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Protein Characteristics
- R132H
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Purification tag / Conjugate
- This IDH1 protein is labelled with His tag.
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Purpose
- Recombinant Human IDH1 Protein (R132H, C-8His)
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Sequence
- Met1-Leu414(Arg132His)
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Characteristics
- Recombinant Human Isocitrate Dehydrogenase [NADP] Cytoplasmic is produced by our E.coli expression system and the target gene encoding Met1-Leu414(Arg132His) is expressed with a 8His tag at the C-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) (AA 2-414) protein (His tag)
IDH1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE,> 90 % as determined by HPLC
Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) (AA 341-414) protein (His-IF2DI Tag)IDH1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) (AA 1-414) protein (His tag)IDH1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) (AA 1-414) protein (GST tag)IDH1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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Restrictions
- For Research Use only
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Format
- Frozen, Liquid
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Buffer
- Supplied as a 0.2 μm filtered solution of 50 mM Tris, 200 mM NaCl, 10 % glycerol, pH 8.0.
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Storage
- -20 °C
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Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- IDH1 (Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1))
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Alternative Name
- IDH1
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Background
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Background: Isocitrate Dehydrogenase [NADP] Cytoplasmic (IDH1) belongs to the isocitrate and isopropylmalate dehydrogenases family. IDH1 exists as a homodimer, binding one magnesium or manganese ion per subunit. Mutations of IDH1 have been shown to cause metaphyseal chondromatosis with aciduria and are involved in the development of glioma. IDH plays a role in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the α-hydroxylation of phytanic acid.
Synonym: Isocitrate Dehydrogenase [NADP] Cytoplasmic, IDH, Cytosolic NADP-Isocitrate Dehydrogenase, IDP, NADP(+)-Specific ICDH, Oxalosuccinate Decarboxylase, IDH1, PICD
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Molecular Weight
- 48.1 kDa
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UniProt
- O75874
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Pathways
- Warburg Effect
Target
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