Lactoferrin Protein (His tag)

Catalog No. ABIN7320159

Recombinant Lactoferrin protein expressed in HEK-293 Cells.

Quick Overview for Lactoferrin Protein (His tag) (ABIN7320159)

Target: Lactoferrin (LTF) (Lactotransferrin (LTF))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purity: > 92 % as determined by SDS-PAGE

Product Details

Purification tag / Conjugate: This Lactoferrin protein is labelled with His tag.

Purpose: Recombinant Mouse Lactotransferrin/LTF Protein (His Tag)

Sequence: Met 1-Gln 707

Characteristics: A DNA sequence encoding the mouse LTF (AAH06904.1) (Met 1-Gln 707) was expressed, with a C-terminal polyhistidine tag.

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Lactoferrin (LTF) (Lactotransferrin (LTF))

Alternative Name: Lactotransferrin/LTF

Background:

Background: Lactotransferrin, also known as Lactoferrin, Talalactoferrin and LTF, is a secreted protein which belongs to the transferrin family. Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. Lactotransferrin has antimicrobial activity which depends on the extracellular cation concentration. Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while lactoferroxin B and lactoferroxin C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors. Lactoferrin / LTF is a globular glycoprotein that is widely represented in various secretory fluids, such as milk, saliva, tears, and nasal secretions. Lactoferrin / LTF is also present in secondary granules of PMN and is secreted by some acinar cells. Lactoferrin / LTF can be purified from milk or produced recombinantly. Human colostrum has the highest concentration, followed by human milk, then cow milk. Lactoferrin / LTF is one of the components of the immune system of the body, it has antimicrobial activity (bacteriocide, fungicide) and is part of the innate defense, mainly at mucoses. In particular, lactoferrin provides antibacterial activity to human infants. Lactoferrin interacts with DNA and RNA, polysaccharides and heparin, and shows some of its biological functions in complexes with these ligands.

Synonym: Csp82,Lf,MMS10R,Ms10r

Molecular Weight: 77.2 kDa

Pathways: Transition Metal Ion Homeostasis