LTA Protein
Quick Overview for LTA Protein (ABIN7319132)
Target
See all LTA ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Purpose
- Recombinant Human TNF beta/TNFB Protein (Active)
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Sequence
- Leu35-Leu205
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Characteristics
- Recombinant Human Tumor Necrosis Factor beta is produced by our E.coli expression system and the target gene encoding Leu35-Leu205 is expressed.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Biological Activity Comment
- Measured in a cytotoxicity assay using L-929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is 20-80 pg/ml.
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Lymphotoxin-alpha (LTA) (Active) protein
LTA Origin: Chemical Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS-PAGE Func Active
Lymphotoxin-alpha (LTA) (AA 58-205) protein (His-DYKDDDDK-Strep II Tag)LTA Origin: Human Host: HEK-293T Cells Recombinant WB, SDS, ELISA, PI
Lymphotoxin-alpha (LTA) (AA 35-205) protein (His tag)LTA Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Lymphotoxin-alpha (LTA) (AA 34-202) protein (His tag)LTA Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Lymphotoxin-alpha (LTA) (AA 1-205) protein (GST tag)LTA Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Lymphotoxin-alpha (LTA) (AA 35-205) (Active) protein (His tag)LTA Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90% by SDS-PAGE SDS, AcA Active
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- LTA (Lymphotoxin-alpha (LTA))
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Alternative Name
- TNF beta/TNFB
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Target Type
- Chemical
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Background
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Background: Tumor Necrosis Factor β (TNF-β) is a secreted protein belonging to the tumor necrosis factor family. TNF-β binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM in homotrimeric form, binds to TNFRSF3/LTBR in heterotrimeric form with LTB. TNF-β forms heterotrimers with lymphotoxin-beta, which anchors TNF-β to the cell surface. TNF-β mediates the inflammatory, immunostimulatory, and antiviral response, involves in the formation of second lymphoid organs during development, has a role in apoptosis. TNF-β is produced by lymphocytes and cytotoxic for a variety of tumor cells in vitro and in vivo.
Synonym: Lymphotoxin-Alpha, LT-Alpha, TNF-Beta, Tumor Necrosis Factor Ligand Superfamily Member 1, LTA, TNFB, TNFSF1
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Molecular Weight
- 18.8 kDa
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UniProt
- P01374
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Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Target
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