CD301b/MGL2 Protein (His tag)

Catalog No. ABIN7320803

This Recombinant CD301b/MGL2 protein is expressed in Human Cells.

Quick Overview for CD301b/MGL2 Protein (His tag) (ABIN7320803)

Target: CD301b/MGL2 (MGL2) (Macrophage Galactose N-Acetyl-Galactosamine Specific Lectin 2 (MGL2))

Protein Type: Recombinant

Origin: Mouse

Source: Human Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This CD301b/MGL2 protein is labelled with His tag.

Purpose: Recombinant Mouse MGL2/CD301b Protein (His Tag)

Sequence: Ser72-Pro232

Characteristics: Recombinant Mouse MGL2 is produced by our Mammalian expression system and the target gene encoding Ser72-Pro232 is expressed with a 6His tag at the N-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CD301b/MGL2 (MGL2) (Macrophage Galactose N-Acetyl-Galactosamine Specific Lectin 2 (MGL2))

Alternative Name: MGL2/CD301b

Background:

Background: Macrophage galactose N-acetyl-galactosamine-specific lectin 2(Mgl2), also known as CD301b, is a 38 kDa member that belongs to the C-type lectin family. Two MGL proteins are encoded by separate genes in the mouse, but share 91 % amino acid (aa) identity in the extracellular domain (ECD). Only one MGL occurs in human and rat and this MGL is structurally more similar to mouse MGL1 than MGL2. However, human MGL and mouse MGL2 both bind specifically to terminal GalNAc residues, in contrast with mouse MGL1 which binds Lewis X. GalNAc recognition is likely to be important in dendritic cell-mediated tolerance to self-gangliosides as well as recognition of tumor antigens and parasite glycoproteins.

Synonym: Mgl2,CD301b,Macrophage galactose N-acetyl-galactosamine-specific lectin 2,Macrophage Galactose-type C-lectin 2

Molecular Weight: 30.9 kDa

UniProt: Q8JZN1