METAP1 Protein

Catalog No. ABIN7319523

This Recombinant METAP1 protein is produced in Escherichia coli (E. coli).

Quick Overview for METAP1 Protein (ABIN7319523)

Target: METAP1 (Methionyl Aminopeptidase 1 (METAP1))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Purpose: Recombinant Human METAP1 Protein

Sequence: Met1-Phe386

Characteristics: Recombinant Human METAP1 is produced by our E.coli expression system and the target gene encoding Met1-Phe386 is expressed.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Tris,500 mM NaCl,10 % glycerol, pH 8.0.

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Target Details

Target: METAP1 (Methionyl Aminopeptidase 1 (METAP1))

Alternative Name: METAP1

Background:

Background: Methionine Aminopeptidase 1 is a member of the M24 family of metalloproteases. METAP1 plays an important role in G(2)/M phase regulation of the cell cycle and may serve as a promising target for the discovery and development of new anticancer agents. METAP1 and METAP2 have different substrate specificity due to the differences in both size and shape of the active sites. The proteolytic removal of N-terminal methionine from nascent peptides is catalyzed by a family of enzymes known as methionine aminopeptidases (MetAPs) and is essential for cell growth. Inhibition of METAPs provides a novel strategy in developing anti-cancer drugs.

Synonym: Methionine aminopeptidase 1, MAP 1, MetAP 1, Peptidase M 1, METAP1,MAP1A,MetAP1A

Molecular Weight: 43.2 kDa

UniProt: P53582

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling