NFASC Protein (His tag)
Quick Overview for NFASC Protein (His tag) (ABIN7317169)
Target
See all NFASC ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This NFASC protein is labelled with His tag.
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Purpose
- Recombinant Human NFASC/Neurofascin protein (His Tag)
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Sequence
- Met 1-Gln939
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Characteristics
- A DNA sequence encoding the human NFASC (O94856-12) (Met1-Gln939) was expressed with a C-terminal polyhistidine tag.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Neurofascin (NFASC) protein (Fc Tag)
NFASC Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Neurofascin (NFASC) (AA 1239-1347) protein (His tag)NFASC Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Neurofascin (NFASC) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)NFASC Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Neurofascin (NFASC) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)NFASC Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from sterile PBS, pH 7.4
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- NFASC (Neurofascin (NFASC))
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Alternative Name
- NFASC/Neurofascin
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Background
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Background: NFASC, also known as neurofascin, belongs to the immunoglobulin superfamily, L1/neurofascin/NgCAM family. It contains 5 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains. NFASC functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. NFASC links the AIS extracellular matrix to the intracellular cytoskeleton.
Synonym: NF,NRCAML
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Molecular Weight
- 104.4 kDa
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Pathways
- Cell-Cell Junction Organization
Target
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