NKG2D Ligand 1-Like (LOC100738183) protein (Fc Tag)

Catalog No. ABIN7318833

This Recombinant NKG2D Ligand 1-Like protein is produced in Human Cells.

Quick Overview for NKG2D Ligand 1-Like (LOC100738183) protein (Fc Tag) (ABIN7318833)

Target: NKG2D Ligand 1-Like (LOC100738183)

Protein Type: Recombinant

Origin: Human

Source: Human Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: Fc Tag

Purpose: Recombinant Human NKG2DL/ULBP-1 Protein (Fc Tag)

Sequence: Gly26-Pro215

Characteristics: Recombinant Human UL16 Binding Protein-1/NKG2D ligand 1 is produced by our Mammalian expression system and the target gene encoding Gly26-Pro215 is expressed with a Fc tag at the C-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: NKG2D Ligand 1-Like (LOC100738183)

Alternative Name: NKG2DL/ULBP-1

Background:

Background: NKG2D ligand 1, also called ULBP1, is a member of UL16-binding protein (ULBP) family which has also been termed the retinoic acid early transcript 1 (RAET1) family. Unlike the classical MHC class I molecules and the MIC molecules possess α1, α2 and α3 domains, ULBP/RAET1 family members lack α3 domain. ULBP1 is recognized by the activating receptor NKG2D on the surface of cytotoxic natural killer (NK) and T cells, and then promotes the lysis of cells expressing ULBP1 which is important for the immune surveillance. ULBP1 and several other family members, ULBP2 and ULBP5, own the ability to bind the human cytomegalovirus (CMV) UL16 glycoprotein. The human CMV glycoprotein UL16 binds to intracellular ULBP1 and so inhibits its expression at the cell surface, which reduces the susceptibility of the virus-infected cell to cytotoxic destruction by NK cells. The expression of ULBP1 has been found on some tumor cells and is implicated in tumor surveillance.

Synonym: NKG2D ligand 1,NKG2DL1,ALCAN-beta,Retinoic acid early transcript 1I,UL16-binding protein 1,ULBP1

Molecular Weight: 49.4 kDa

UniProt: Q9BZM6