NOL3 Protein
Quick Overview for NOL3 Protein (ABIN7318841)
Target
See all NOL3 ProteinsProtein Type
Origin
Source
Purity
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Purpose
- Recombinant Human NOL3 Protein
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Sequence
- Met 1-Ser208
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Characteristics
- Recombinant Human Nucleolar Protein 3 is produced by our E.coli expression system and the target gene encoding Met1-Ser208 is expressed.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3) (AA 1-208) protein (His-IF2DI Tag)
NOL3 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3) (AA 1-208) protein (GST tag)NOL3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3) (AA 1-208) protein (His-SUMO Tag)NOL3 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3) (Transcript Variant 3) protein (His tag)NOL3 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3) protein (Myc-DYKDDDDK Tag)NOL3 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Frozen, Liquid
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Buffer
- Supplied as a 0.2 μm filtered solution of 25 mM TrisHCl, 1 mM DTT, 1 mM EDTA, 2 mM β-ME, 20 % Glycerol, pH 7.5.
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Storage
- -20 °C
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Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- NOL3 (Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3))
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Alternative Name
- NOL3
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Background
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Background: Nucleolar protein 3 is encoded by NOL3 gene. Multiple transcript variants encoding different isoforms have been found for this gene. So far, Nucleolar protein 3 has show to have two Isoforms. Isoform 1 may be involved in RNA splicing. Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death. It inhibits extrinsic apoptotic pathways through two different ways. Firstly, it by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly. Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation. It has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53.
Synonym: Nucleolar Protein 3, Apoptosis Repressor With CARD, Muscle-Enriched Cytoplasmic Protein, Myp, Nucleolar Protein of 30 kDa, Nop30
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Molecular Weight
- 22.6 kDa
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UniProt
- O60936
Target
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