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Oncomodulin Protein (OCM) (His tag)

Recombinant Oncomodulin protein expressed in Escherichia coli (E. coli).
Catalog No. ABIN7318847
$474.72
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Quick Overview for Oncomodulin Protein (OCM) (His tag) (ABIN7318847)

Target

See all Oncomodulin (OCM) Proteins
Oncomodulin (OCM)

Protein Type

Recombinant

Origin

  • 6
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Source

  • 14
  • 9
  • 1
Escherichia coli (E. coli)

Purity

> 95 % as determined by reducing SDS-PAGE.
  • Purification tag / Conjugate

    This Oncomodulin protein is labelled with His tag.

    Purpose

    Recombinant Human Oncomodulin-1/OCM Protein (His Tag)

    Sequence

    Met 1-Ser109

    Characteristics

    Recombinant Human Oncomodulin-1 is produced by our E.coli expression system and the target gene encoding Met1-Ser109 is expressed with a 6His tag at the N-terminus.

    Endotoxin Level

    < 1.0 EU per μg as determined by the LAL method.
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  • Restrictions

    For Research Use only
  • Format

    Lyophilized

    Reconstitution

    Please refer to the printed manual for detailed information.

    Buffer

    Lyophilized from a 0.2 μm filtered solution of 50 mM Tris, 100 mM NaCl, pH 7.5.

    Storage

    4 °C,-20 °C,-80 °C

    Storage Comment

    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target

    Oncomodulin (OCM)

    Alternative Name

    Oncomodulin-1/OCM

    Background

    Background: Oncomodulin-1 (OM) is a small, calcium-binding protein and a macrophage-derived growth factor, which can promote axon regeneration in retinal ganglion cells. Oncomodulin-1 is constitutively secreted by activated macrophages in the vitreous and retina in response to inflammatory conditions that promote optic nerve regeneration. Oncomodulin-1 binds RGCs with high affinity in vitro, but only when cAMP is pharmacologically elevated or if the membrane is permeabilized allowing Oncomodulin-1 access to the cytosolic compartment. Oncomodulin-1 is a member of the superfamily of calmodulin proteins and is a high-affinity calcium ion-binding protein and contains 2 EF-hand domains. OM is found in early embryonic cells in the placenta and also in tumors. It has some calmodulin-like activity with respect to enzyme activation and growth regulation.

    Synonym: Oncomodulin-1, OM, Parvalbumin Beta, OCM, OCM1, OCMN

    Molecular Weight

    14.3 kDa

    UniProt

    P0CE72
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