PMM2 Protein (His tag)

Catalog No. ABIN7318900

Recombinant PMM2 protein expressed in Escherichia coli (E. coli).

Quick Overview for PMM2 Protein (His tag) (ABIN7318900)

Target: PMM2 (Phosphomannomutase 2 (PMM2))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This PMM2 protein is labelled with His tag.

Purpose: Recombinant Human PMM2 Protein (His Tag)

Sequence: Met 1-Ser246

Characteristics: Recombinant Human Phosphomannomutase 2 is produced by our E.coli expression system and the target gene encoding Met1-Ser246 is expressed with a 6His tag at the C-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl, 150 mM NaCl, pH 8.0.

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Target Details

Target: PMM2 (Phosphomannomutase 2 (PMM2))

Alternative Name: PMM2

Background:

Background: Phosphomannomutase 2 (PMM2) is an enzyme that is a member of the highly variable methyltransferase superfamily. PMM2 is a cytoplasmic protein and catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate.In addition, PMM2 involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose that required for a number of critical mannosyl transfer reactions. Defects in PMM2 can results in congenital disorder of glycosylation type 1A (CDG1A). Congenital disorders of glycosylation are metabolic deficiencies in glycoprotein biosynthesis that usually cause severe mental and psychomotor retardation.

Synonym: Phosphomannomutase 2, PMM 2, PMM2

Molecular Weight: 29.1 kDa

UniProt: O15305