PSPH Protein
Quick Overview for PSPH Protein (ABIN7317234)
Target
See all PSPH ProteinsProtein Type
Origin
Source
Purity
-
-
Purpose
- Recombinant Human PSPH Protein
-
Sequence
- Met 1-Glu 225
-
Characteristics
- A DNA sequence encoding the human PSPH (P78330) (Met 1-Glu 225) was expressed and purified.
-
-
Want other Options for this Protein ?
!Discover Our Predefined Custom Proteins and Custom Protein Services!ProductExpression SystemConjugateOriginPrice starts atExpression System HEK-293 CellsConjugate His tagOrigin HumanPrice starts at $12,595.45Expression System Cell-free protein synthesis (CFPS)Conjugate Strep TagOrigin HumanPrice starts at $20,480.57Your project requires further customization? Contact us and discover our custom protein solutions
-
Phosphoserine Phosphatase (PSPH) (AA 1-225) protein (His tag)
custom-made PSPH Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Phosphoserine Phosphatase (PSPH) (AA 1-225) protein (His tag)custom-made PSPH Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Phosphoserine Phosphatase (PSPH) (AA 1-225) protein (GST tag)PSPH Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Phosphoserine Phosphatase (PSPH) (AA 1-382) protein (His tag)PSPH Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % pure SDS
Phosphoserine Phosphatase (PSPH) protein (Myc-DYKDDDDK Tag)PSPH Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
-
-
Restrictions
- For Research Use only
-
-
-
Format
- Lyophilized
-
Reconstitution
- Please refer to the printed manual for detailed information.
-
Buffer
- Lyophilized from sterile PBS, pH 7.5
-
Storage
- 4 °C,-20 °C,-80 °C
-
Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
-
- PSPH (Phosphoserine Phosphatase (PSPH))
-
Alternative Name
- PSPH
-
Background
-
Background: Phosphoserine phosphatase (PSPH) belongs to a subfamily of the phosphotransferases. PSPH is the rate-limiting enzyme in l-serine biosynthesis. It has previously been found that Phosphoserine phosphatase (PSPH) plays a role in epidermal homeostasis. Phosphoserine phosphatase (PSP) catalyzes the hydrolysis of phosphoserine to serine. Phosphoserine phosphatase (PSPH) expression has been examined in human-mouse somatic cell hybrids retaining different combination of human chromosomes. Phosphoserine phosphatase (PSPH) is expressed throughout the proliferative layer of the epidermis and hair follicles in rodent and human skin and is highly induced in SCC. In keratinocytes, Phosphoserine phosphatase (PSPH) is a cytoplasmic protein that primarily localizes to endosomes and is present primarily as a homodimer. Knock down of Phosphoserine phosphatase (PSPH) dramatically diminished SCC cell proliferation and cyclin D1 levels in the presence of exogenous of l-serine production suggesting a non-canonical role for Phosphoserine phosphatase (PSPH) in epithelial carcinogenesis. Phosphoserine phosphatase (PSPH) is highly induced in proliferative normal keratinocytes and in skin tumors. Phosphoserine phosphatase (PSPH) appears to be critical for the proliferation of SCC cells, however, this phenomenon may not involve the phosphoserine metabolic pathway.
Synonym: Phosphoserine Phosphatase, PSP, PSPase, L-3-Phosphoserine Phosphatase, O-Phosphoserine Phosphohydrolase, PSPH
-
Molecular Weight
- 25 kDa
-
UniProt
- P78330
-
Pathways
- Warburg Effect
Target
-
