Podoplanin Protein (PDPN) (Fc Tag,ECD)

Catalog No. ABIN7321058

This Recombinant Podoplanin protein is produced in HEK-293 Cells.

Quick Overview for Podoplanin Protein (PDPN) (Fc Tag,ECD) (ABIN7321058)

Target: Podoplanin (PDPN)

Protein Type: Recombinant

Origin: Rat

Source: HEK-293 Cells

Purity: > 95 % as determined by SDS-PAGE

Product Details

Purification tag / Conjugate: This Podoplanin protein is labelled with Fc Tag,ECD.

Purpose: Recombinant Rat Podoplanin/PDPN Protein (ECD, Fc Tag)

Sequence: Met1-Leu135

Characteristics: A DNA sequence encoding the rat Pdpn (NP_062231.1) (Met1-Leu135) was expressed with the Fc region of human IgG1 at the C-terminus.

Endotoxin Level: < 1.0 EU per μg protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Podoplanin (PDPN)

Alternative Name: Podoplanin/PDPN

Background:

Background: Podoplanin, also known as PDPN, is a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined. Alternatively spliced transcript variants encoding different isoforms have been identified.PDPN is a mucin-type glycoprotein negatively charged by extensive O-glycosylation and a high content of sialic acid, which expresses the adhesive property. It is selectively expressed in lymphatic endothelium as well as lymphangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. PDPN may contribute to form odontoblastic fiber or function as the anchorage to the tooth development and in proliferating epithelial cells of cervical loop and apical bud. The intensity of podoplanin expression is negatively correlated with the expression of CD34 and factor VIII. Podoplanin would be useful as a diagnostic marker for epithelioid hemangioendothelioma in liver tumors.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Synonym: Gp38;Ots8

Molecular Weight: 38.6 kDa

NCBI Accession: NP_062231

Pathways: Dicarboxylic Acid Transport