Prokineticin 1 Protein (Prok1) (His tag)

Catalog No. ABIN7318098

Recombinant Prokineticin 1 protein expressed in Baculovirus infected Insect Cells.

Quick Overview for Prokineticin 1 Protein (Prok1) (His tag) (ABIN7318098)

Target: Prokineticin 1 (Prok1)

Protein Type: Recombinant

Origin: Human

Source: Baculovirus infected Insect Cells

Purity: > 89 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This Prokineticin 1 protein is labelled with His tag.

Purpose: Recombinant Human EG-VEGF/prokineticin-1 Protein (His Tag)

Sequence: Met 1-Phe105

Characteristics: A DNA sequence encoding the human EG-VEGF (Met 1-Phe105) (P58294) was expressed, with a C-terminal polyhistidine tag.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 0.02 % Tween-80, 10 % glycerol, 1 mM DTT 1. Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. 2. Please contact us for any concerns or special requirements.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Prokineticin 1 (Prok1)

Alternative Name: EG-VEGF/prokineticin-1

Background:

Background: EG-VEGF, also known as prokineticin-1, is a member of the AVIT (prokineticin) family. Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. EG-VEGF can be detected in the steroidogenic glands, ovary, testis, adrenal and placenta. EG-VEGF has little or no effect on a variety of other endothelial and non-endothelial cell types. It induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. It directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. EG-VEGF may play a role in placentation. It may also function in normal and pathological testis angiogenesis. It positively regulates PTGS2 expression and prostaglandin synthesis.

Synonym: EGVEGF,PK1,PRK1

Molecular Weight: 11 kDa

UniProt: P58294