Prostate Specific Antigen Protein (PSA) (AA 25-261) (His tag)

Catalog No. ABIN7318944

Product Details

Target: Prostate Specific Antigen (PSA)

Protein Type: Recombinant

Protein Characteristics: AA 25-261

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This Prostate Specific Antigen protein is labelled with His tag.

Purpose: Recombinant Human PSA/KLK3 Protein (aa 25-261, His Tag)

Sequence: Ile25-Pro261

Characteristics: Recombinant Human Kallikrein-3/Prostate-specific antigen is produced by our Mammalian expression system and the target gene encoding Ile25-Pro261 is expressed with a 6His tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHcl, 150 mM NaCl,1 mM CaCl2, pH 7.5.

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Target Details

Target: Prostate Specific Antigen (PSA)

Alternative Name: PSA/KLK3 (PSA Products)

Background:

Background: KLK3, also known as APS, is short for Prostate-specific antigen. It is a 261 aa. protein which belongs to the peptidase S1 family and Kallikrein subfamily. This protein has 5 isforms produced by alternative splicing. It is a secreted protein and can forms a heterodimer with SERPINA5 which can inhibit its activity. KLK3 is also strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders. KLK3 can hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.

Synonym: APS,Hk3,KLK2A1,PSA,Prostate-Specific Antigen, PSA, Gamma-Seminoprotein, Seminin, Kallikrein-3, P-30 Antigen, Semenogelase,

Molecular Weight: 27.1 kDa

UniProt: P07288

Pathways: Complement System