Sclerostin Protein (SOST) (His tag)

Catalog No. ABIN7197841

This Recombinant Sclerostin protein is expressed in HEK-293 Cells.

Quick Overview for Sclerostin Protein (SOST) (His tag) (ABIN7197841)

Target: Sclerostin (SOST)

Protein Type: Recombinant

Origin: Rat

Source: HEK-293 Cells

Purity: > 97 % as determined by SDS-PAGE

Product Details

Purification tag / Conjugate: This Sclerostin protein is labelled with His tag.

Purpose: Recombinant Rat Sclerostin/SOST Protein (His Tag)

Sequence: Met 1-Tyr 213

Characteristics: A DNA sequence encoding the rat SOST (NP_085073.1) (Met 1-Tyr 213) was expressed, fused with a polyhistidine tag at the C-terminus.

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Sclerostin (SOST)

Alternative Name: Sclerostin/SOST

Background:

Background: Sclerostin, the protein product of the SOST gene, is a potent inhibitor of bone formation. Sclerostin protein is widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteeoblasts differentiated for 21 days, and was originally identified as an important regulator of bone remodeling, homeostasis, and links bone resorption and bone apposition. Recent studies have revealed that Sclerostin protein inhibits the bone growth probably by binding to the extracellular domain of the Wnt coreceptors LRP5 and LRP6 and disrupting Wnt-induced Frizzled-LRP complex formation.

Synonym: SOST

Molecular Weight: 23 kDa

NCBI Accession: NP_085073