SIRPb2 Protein (Fc Tag)

Catalog No. ABIN7319832

Recombinant SIRPb2 protein expressed in Human Cells.

Quick Overview for SIRPb2 Protein (Fc Tag) (ABIN7319832)

Target: SIRPb2 (Signal-Regulatory Protein beta 2 (SIRPb2))

Protein Type: Recombinant

Origin: Human

Source: Human Cells

Purity: >95 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This SIRPb2 protein is labelled with Fc Tag.

Purpose: Recombinant Human SIRPB2 (C-Fc)

Sequence: Gln33-Gly287

Characteristics: Recombinant Human Signal-regulatory Protein Beta-2 is produced by our Mammalian expression system and the target gene encoding Gln33-Gly287 is expressed with a Fc tag at the C-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: SIRPb2 (Signal-Regulatory Protein beta 2 (SIRPb2))

Alternative Name: SIRPB2

Background:

Background: Signal-regulatory protein beta-2(SIRP-beta-2), is a monomeric single pass type I membrane glycoprotein, belongs to the SIRP/SHPS (CD172) family of the immunoglobulin (Ig) superfamily. The SIRP family are paired receptors that have similar extracellular domains but differing C-terminal domains and functions. A positively charged residue within the transmembrane domain, in analogy to SIRP-beta-1, is implicated to mediate interaction with the adaptor DAP12 protein, which contains immunoreceptor tyrosine-based activation motifs (ITAMs) . Proteins in the SIRP family are typically expressed in immune cells, especially in the myeloid lineages . Based on expression patterns, SIRPs are thought to have roles in immune regulation. SIRP family members role in innate immunity and host defense has potential significance as a therapeutic target in cancer and inflammation. There are currently no known mouse or rat homologs for this protein.

Synonym: dJ776F14.2, PTPN1L, PTPNS1L3, Signal-Regulatory Protein Beta 2, Signal-Regulatory Protein Beta-2, SIRP beta 2, SIRP-beta-2, SIRPG

Molecular Weight: 55.2 kDa

UniProt: Q5JXA9