SPEG Protein (His tag)

Catalog No. ABIN7198099

This Recombinant SPEG protein is expressed in Escherichia coli (E. coli).

Quick Overview for SPEG Protein (His tag) (ABIN7198099)

Target: SPEG (SPEG Complex Locus (SPEG))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 85 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This SPEG protein is labelled with His tag.

Purpose: Recombinant Human SPEG/APEG-1 Protein (His Tag)

Sequence: Met 1-Glu 113

Characteristics: A DNA sequence encoding the human SPEG isoform 3 (Q15772-4) (Met 1-Glu 113) was fused with a polyhistidine tag at the C-terminus.

Application Details

Restrictions: For Research Use only

Handling

Format: Frozen, Liquid

Buffer: Supplied as sterile PBS, pH 7.4

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Target Details

Target: SPEG (SPEG Complex Locus (SPEG))

Alternative Name: SPEG/APEG-1

Background:

Background: Striated muscle preferentially expressed protein kinase, also known as aortic preferentially expressed protein 1, APEG-1, SPEG and KIAA1297, is a protein which belongs to the protein kinase superfamily and CAMK Ser/Thr protein kinase family. SPEG / APEG-1 contains two fibronectin type-III domains, nine Ig-like (immunoglobulin-like) domains, two protein kinase domains. Isoform 1 of SPEG is preferentially expressed in striated muscle. Non-kinase form such as isoform 3 of SPEG is predominantly expressed in the aorta. Isoform 3 of SPEG appears to be expressed only in highly differentiated ASMC in normal vessel walls and down-regulated in dedifferentiated ASMC. Isoform 3 of SPEG may have a role in regulating the growth and differentiation of arterial smooth muscle cells. Isoform 3 of SPEG is quickly down-regulated in response to vascular injury, when ASMC cells change from a quiescent to a proliferative phenotype.

Synonym: APEG-1;APEG1;BPEG;CNM5;SPEGalpha;SPEGbeta

Molecular Weight: 14 kDa