STUB1 Protein
Quick Overview for STUB1 Protein (ABIN7318418)
Target
See all STUB1 ProteinsProtein Type
Origin
Source
Purity
-
-
Purpose
- Recombinant Human STUB1 Protein
-
Sequence
- Met 1-Tyr303
-
Characteristics
- Recombinant Human E3 Ubiquitin-Protein Ligase CHIP is produced by our E.coli expression system and the target gene encoding Met1-Tyr303 is expressed.
-
Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
-
-
Want other Options for this Protein ?
!Discover Our Predefined Custom Proteins and Custom Protein Services!ProductExpression SystemConjugateOriginPrice starts atExpression System HEK-293 CellsConjugate His tagOrigin HumanPrice starts at $13,686.36Expression System Cell-free protein synthesis (CFPS)Conjugate Strep TagOrigin HumanPrice starts at $20,480.57Your project requires further customization? Contact us and discover our custom protein solutions
-
STIP1 Homology and U-Box Containing Protein 1 (STUB1) (AA 1-304) protein (His tag)
custom-made STUB1 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
STIP1 Homology and U-Box Containing Protein 1 (STUB1) (AA 1-303) protein (His tag)custom-made STUB1 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
STIP1 Homology and U-Box Containing Protein 1 (STUB1) (AA 1-303) protein (His tag)STUB1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
STIP1 Homology and U-Box Containing Protein 1 (STUB1) (AA 1-303) protein (GST tag)STUB1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
STIP1 Homology and U-Box Containing Protein 1 (STUB1) protein (Myc-DYKDDDDK Tag)STUB1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
-
-
Restrictions
- For Research Use only
-
-
-
Format
- Frozen, Liquid
-
Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
-
Storage
- -20 °C
-
Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
-
-
- STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))
-
Alternative Name
- STUB1
-
Background
-
Background: E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain, lead to in client substrate ubiquitylation and degradation by the proteasome. CHIP targets misfolded chaperone substrates towards proteasomal degradation. CHIP mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. CHIP plays a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. It also may regulate the receptor stability and activity through proteasomal degradation.
Synonym: E3 Ubiquitin-Protein Ligase CHIP, Antigen NY-CO-7, CLL-Associated Antigen KW-8, Carboxy Terminus of Hsp70-Interacting Protein, STIP1 Homology and U Box-Containing Protein 1, STUB1, CHIP
-
Molecular Weight
- 34.9 kDa
-
UniProt
- Q9UNE7
-
Pathways
- Regulation of Hormone Metabolic Process, Response to Water Deprivation
Target
-
