Tspan-8 Protein (His tag)
Quick Overview for Tspan-8 Protein (His tag) (ABIN7198214)
Target
See all Tspan-8 (TSPAN8) ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This Tspan-8 protein is labelled with His tag.
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Purpose
- Recombinant Human TSPAN8/Tetraspanin 8 Protein (His Tag)
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Sequence
- Lys110-Asn205
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Characteristics
- A DNA sequence encoding the human TSPAN8 (P19075) (Lys110-Asn205) was expressed with an N-terminal polyhistidine tag.
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Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Tetraspanin 8 (TSPAN8) (AA 1-237) protein (His tag)
custom-made TSPAN8 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Tetraspanin 8 (TSPAN8) (AA 1-235) protein (His tag)custom-made TSPAN8 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Tetraspanin 8 (TSPAN8) (AA 110-205) protein (Fc Tag)TSPAN8 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tetraspanin 8 (TSPAN8) proteinTSPAN8 Origin: Human Host: HEK-293 Cells Synthetic Nanodisc
Tetraspanin 8 (TSPAN8) (AA 110-205) protein (GST tag)TSPAN8 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
Tetraspanin 8 (TSPAN8) (AA 1-237) protein (GST tag)TSPAN8 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from sterile PBS, pH 7.4.
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Tspan-8 (TSPAN8) (Tetraspanin 8 (TSPAN8))
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Alternative Name
- TSPAN8/Tetraspanin 8
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Background
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Background: Tetraspanin 8 (TSPAN8) as an important modulator of melanoma invasiveness, and several of its transcriptional regulators, which affect TSPAN8 expression during melanoma progression toward an invasive stage. p53 as a negative regulator of Tspan8 expression. p53 as a regulator of melanoma invasion and the concept that reactivating p53 could provide a strategy for modulating not only proliferative but also invasive capacity in melanoma treatment. Tetraspanin 8 (TSPAN8) is a tumor-associated antigen implicated in tumor progression and metastasis. TSPAN8 may play an important role in mCRC cell invasion. TSPAN8 was overexpressed in human gastric cancer tissues and gastric cancer cell lines compared with the normal. TSPAN8 overexpression promoted cell proliferation and invasion, while TSPAN8 suppression inhibited cell proliferation and invasion. TSPAN8 could activate the ERK MAPK pathway in gastric cancer cells, and MEK-ERK inhibition reversed the effects of TSPAN8 overexpression on cell proliferation and invasion.
Synonym: CO-029,TM4SF3
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Molecular Weight
- 13.4 kDa
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UniProt
- P19075
Target
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