Thrombomodulin Protein (THBD) (His tag)

Catalog No. ABIN7320771

This Recombinant Thrombomodulin protein is expressed in Human Cells.

Quick Overview for Thrombomodulin Protein (THBD) (His tag) (ABIN7320771)

Target: Thrombomodulin (THBD)

Protein Type: Recombinant

Origin: Mouse

Source: Human Cells

Purity: > 90 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This Thrombomodulin protein is labelled with His tag.

Purpose: Recombinant Mouse Thrombomodulin/THBD Protein (His Tag)

Sequence: Leu17-Ser517

Characteristics: Recombinant Mouse Thrombomodulin is produced by our Mammalian expression system and the target gene encoding Leu17-Ser517 is expressed with a 6His tag at the C-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Tris, 150 mM NaCl, pH 8.0.

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Target Details

Target: Thrombomodulin (THBD)

Alternative Name: Thrombomodulin/THBD

Background:

Background: Thrombomodulin is also known as CD141 antigen and blood dendritic cell antigen 3 (BDCA3), which is encoded by the THBD gene. The deduced amino acid sequence of mouse THBD predicts a signal peptide (aa 1 to 16) and a mature chain (aa 17 to 577) that consists of the following domains: C-type lectin, EGF-like, transmembrane and cytoplasmic. Mouse THBD is corresponding to the extracellular portion of the type I membrane protein. Predominantly synthesized by vascular endothelial cells, THBD inhibits coagulation and fibrinolysis. It functions as a cell surface receptor and an essential cofactor for active thrombin, which in turn activates protein C and thrombinactivatable fibrinolysis inhibitor (TAFI), also known as carboxypeptidase B2 (CPB2). In addition, THBD gene polymorphisims are associated with human disease and THBD plays a role in thrombosis, stroke, arteriosclerosis, and cancer.

Synonym: Thrombomodulin, TM, Fetomodulin, CD141, BDCA-3, Thbd

Molecular Weight: 54.6 kDa

UniProt: P15306