TPBG Protein (mFc Tag)

Catalog No. ABIN7319827

This Recombinant TPBG protein is expressed in Human Cells.

Quick Overview for TPBG Protein (mFc Tag) (ABIN7319827)

Target: TPBG (Trophoblast Glycoprotein (TPBG))

Protein Type: Recombinant

Origin: Human

Source: Human Cells

Purity: >95 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This TPBG protein is labelled with mFc Tag.

Purpose: Recombinant Human TPBG/5T4 (C-mFc)

Sequence: Ser32-Ser355

Characteristics: Recombinant Human Trophoblast glycoprotein is produced by our Mammalian expression system and the target gene encoding Ser32-Ser355 is expressed with a mFc tag at the C-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: TPBG (Trophoblast Glycoprotein (TPBG))

Alternative Name: TPBG/5T4

Background:

Background: Trophoblast glycoprotein, also known as TPBG and 5T4, it belongs to the LRR family of proteins. The C-terminus of LRR N-terminal cap (LRRNT) and LRR 1 are essential for the inhibition of the Wnt signaling pathway. TPBG may function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. It expressed by all types of trophoblasts as early as 9 weeks of development. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.

Synonym: 5T4 , 5T4AG, M6P1, WAIF1

Molecular Weight: 61.7 kDa

UniProt: Q13641