Quick Overview for Tyrosine protein (Fc Tag) (ABIN7320915)
Target
Protein Type
Origin
Source
Purity
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Purification tag / Conjugate
- Fc Tag
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Purpose
- Recombinant Mouse Tyrosine-protein kinase receptor UFO/AXL oncogene/UFO (C-FC)
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Sequence
- Ala19-Pro443
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Characteristics
- Recombinant Mouse Tyrosine-protein kinase receptor UFO is produced by our Mammalian expression system and the target gene encoding Ala19-Pro443 is expressed with a Fc tag at the C-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Tyrosine protein (His tag)
Origin: Human Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE.
Tyrosine protein (His tag)Origin: Mouse Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Tyrosine
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Alternative Name
- Tyrosine-
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Target Type
- Amino Acid
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Background
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Background: Axl, also known as Ufo and Ark, is a widely expressed 140 kDa glycoprotein in the TAM receptor tyrosine kinase family. Axl binds the vitamin K-dependent protein Gas6 which triggers tyrosine autophosphorylation of the Axl cytoplasmic domain. Axl functions in dampening the immune response, regulating cytokine secretion, clearing apoptotic cells and debris, and maintaining cell survival. Axl is highly expressed in solid cancers and promotes in vivo tumorigenesis and tumor cell invasiveness. It also functions as a cellular entry receptor for Gas6-opsonized lentiviruses. Axl contributes to cell survival, migration, invasion, metastasis and chemosensitivity justify further investigation of Axl as novel therapeutic targets in cancer. The receptor tyrosine kinase AXL is thought to play a role in metastasis. The soluble AXL receptor as a therapeutic candidate agent for treatment of metastatic ovarian cancer. GAS6/AXL targeting as an effective strategy for inhibition of metastatic tumor progression in vivo.
Synonym: Tyrosine-protein kinase receptor UFO, AXL oncogene, UFO, AXL
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Molecular Weight
- 73.3 kDa
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UniProt
- Q00993
Target
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