Quick Overview for ANGPTL3 Protein (Fc Tag) (ABIN7319869)
Target
See all ANGPTL3 ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This ANGPTL3 protein is labelled with Fc Tag.
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Purpose
- Recombinant Human Angiopoietin-related Protein 3/ANGPTL3 (C-Fc)
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Sequence
- Ser17-Pro220
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Characteristics
- Recombinant Human Angiopoietin-related Protein 3 is produced by our Mammalian expression system and the target gene encoding Ser17-Pro220 is expressed with a Fc tag at the C-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Angiopoietin-Like 3 (ANGPTL3) (AA 17-219) protein (His-Avi Tag)
ANGPTL3 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Angiopoietin-Like 3 (ANGPTL3) (AA 17-219) protein (His-Avi Tag,Biotin)ANGPTL3 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Angiopoietin-Like 3 (ANGPTL3) protein (His tag)ANGPTL3 Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Angiopoietin-Like 3 (ANGPTL3) (AA 17-221) protein (His tag)ANGPTL3 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Angiopoietin-Like 3 (ANGPTL3) (AA 17-460) protein (GST tag)ANGPTL3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Angiopoietin-Like 3 (ANGPTL3) (AA 17-460) protein (His tag)ANGPTL3 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 90% by SDS-PAGE SDS
Angiopoietin-Like 3 (ANGPTL3) (AA 17-220) protein (His tag)ANGPTL3 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE.
Angiopoietin-Like 3 (ANGPTL3) (AA 17-220) (Active) protein (His tag,AVI tag,Biotin)ANGPTL3 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
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Comment
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60-70 kDa
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from a 0.2 μm filtered solution of PBS, 5 % Trehalose, pH 7.4.
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- ANGPTL3 (Angiopoietin-Like 3 (ANGPTL3))
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Alternative Name
- Angiopoietin-related protein 3
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Background
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Background: Angiopoietin-like 3 (ANGPTL3) is a secreted glycoprotein that is structurally related to the angiopoietins. Mature human ANGPTL3 contains an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain. ANGPTL3 is expressed in the liver from early in development through adulthood. Full length ANGPTL3 circulates in the plasma as do the proteolytically separated N-and C-terminal segments containing the coiled coil domain and fibrinogen-like domains,respectively. ANGPTL3 directly inhibits lipoprotein lipase (LPL) and endothelial lipase (EL), enzymes responsible for hydrolyzing circulating triglycerides and HDL phospholipids. ANGPTL3 promotes an increase in circulating triglyceride levels without altering VLDL or HDL secretion or uptake. ANGPTL3 expression in vivo is up-regulated by LXR agonists and down-regulated by insulin, leptin, and agonists of TRβ or PPARβ.
Synonym: Angiopoietin-related protein 3, ANGPTL3, Angiopoietin-5, ANG-5, Angiopoietin-like protein 3, ANGPT5
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Molecular Weight
- 50.7 kDa
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UniProt
- Q9Y5C1
Target
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