ADAM8 Protein (AA 17-658) (His tag)
Quick Overview for ADAM8 Protein (AA 17-658) (His tag) (ABIN7273803)
Target
See all ADAM8 ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 17-658
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Purification tag / Conjugate
- This ADAM8 protein is labelled with His tag.
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Purpose
- Mouse ADAM8 Protein
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Sequence
- Pro17-Ser658
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Characteristics
- Recombinant Mouse ADAM8 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Pro17-Ser658.
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Sterility
- 0.22 μm filtered
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Endotoxin Level
- Less than 1 EU per μg by the LAL method.
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Biological Activity Comment
- Mouse ADAM8 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.,Measured by its ability to cleave a fluorogenic peptide substrate Mca-PLAQAV-Dpa-RSSSR-NH2. The specific activity is > 0.4 pmol/min/μg.,The purity of Mouse ADAM8 is greater than 95% as determined by SEC-HPLC.
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ADAM Metallopeptidase Domain 8 (ADAM8) (AA 17-655) protein (His tag)
ADAM8 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
ADAM Metallopeptidase Domain 8 (ADAM8) (AA 188-373) protein (His-IF2DI Tag)ADAM8 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
ADAM Metallopeptidase Domain 8 (ADAM8) (AA 17-497) protein (His tag)ADAM8 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Supplied as 0.22μm filtered solution in 20 mM Tris, 5 mM CaCl2, 75 mM NaCl, 50 % Glycerol ( pH 7.5).
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Storage
- -80 °C
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Storage Comment
- Valid for 12 months from date of receipt when stored at -80°C.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
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Expiry Date
- 12 months
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- ADAM8 (ADAM Metallopeptidase Domain 8 (ADAM8))
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Alternative Name
- ADAM8
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Background
- A Disintegrin And Metalloproteinase (ADAM) proteases constitute a family of multifunctional, membrane-bound proteins with traditional sheddase functions. Their protumorigenic potential has been attributed to both, essential (ADAM10 and ADAM17) and 'dispensable' ADAM proteases (ADAM8, 9, 12, 15, and 19). Of specific interest in this review is the ADAM proteinase ADAM8 that has been identified as a significant player in aggressive malignancies including breast, pancreatic, and brain cancer.
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Molecular Weight
- 71.7 kDa. The protein migrates to 55-70 kDa based on Bis-Tris PAGE result.
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UniProt
- Q05910
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Pathways
- Activation of Innate immune Response, M Phase
Target
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