Aspartate beta Hydroxylase Protein (AA 341-758) (His tag)
Quick Overview for Aspartate beta Hydroxylase Protein (AA 341-758) (His tag) (ABIN7273878)
Target
See all Aspartate beta Hydroxylase (ASPH) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 341-758
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Purification tag / Conjugate
- This Aspartate beta Hydroxylase protein is labelled with His tag.
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Purpose
- Human ASPH Protein
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Sequence
- Ile341-Ile758
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Characteristics
- Recombinant Human ASPH Protein is expressed from E.coli with His tag at the N-Terminus.It contains Ile341-Ile758.
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Sterility
- 0.22 μm filtered
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Endotoxin Level
- Less than 1 EU per ug by the LAL method.
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Biological Activity Comment
- Human ASPH on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.,The purity of Human ASPH is greater than 95% as determined by SEC-HPLC.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Supplied as 0.22μm filtered solution in 20 mM Tris, 500 mM NaCl ( pH 7.4).
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Storage
- -80 °C
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Storage Comment
- Valid for 12 months from date of receipt when stored at -80°C., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
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Expiry Date
- 12 months
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- Aspartate beta Hydroxylase (ASPH) (Aspartate beta-Hydroxylase (ASPH))
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Alternative Name
- ASPH
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Background
- Aspartate β-hydroxylase (ASPH) is silent in normal adult tissues only to re-emerge during oncogenesis where its function is required for generation and maintenance of malignant phenotypes. Exosomes enable prooncogenic secretome delivering and trafficking for long-distance cell-to-cell communication.Expression profiling of Notch signaling components positively correlates with ASPH expression in breast cancer patients, confirming that ASPH-Notch axis acts functionally in breast tumorigenesis.
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Molecular Weight
- 49.2 kDa same as Bis-Tris PAGE result.
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UniProt
- Q12797
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Pathways
- Positive Regulation of Endopeptidase Activity
Target
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