Poliovirus Receptor Protein (PVR) (AA 28-343) (His tag)

Catalog No. ABIN7274060

Product Details

Target: Poliovirus Receptor (PVR)

Protein Type: Recombinant

Protein Characteristics: AA 28-343

Origin: Rhesus Monkey

Source: HEK-293 Cells

Purification tag / Conjugate: This Poliovirus Receptor protein is labelled with His tag.

Purpose: Rhesus macaque CD155/PVR Protein

Sequence: Asp28-Asn343

Characteristics: Recombinant Rhesus macaque CD155/PVR Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Asp28-Asn343.

Purity: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1EU per μg by the LAL method.

Biological Activity Comment: The affinity constant of 0.234 μM as determined in SPR assay (Biacore T200). See testing image for detail.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: Poliovirus Receptor (PVR)

Alternative Name: CD155 (PVR Products)

Background: CD155 is a cell surface adhesion molecule functioning in tumor cell migration, invasion, and metastasis, and not surprisingly, is also designated as a common tumor-associated antigen. CD155 is also recognized by NK cells to induce their cytotoxicity. CD155 is also commonly referred to as the "poliovirus receptor," or PVR.

Molecular Weight: 35.5 kDa. Due to glycosylation, the protein migrates to 46-60 kDa based on Tris-Bis PAGE result.

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Cancer Immune Checkpoints, SARS-CoV-2 Protein Interactome