LI Cadherin Protein (AA 23-667) (His tag)
-
- Target See all LI Cadherin Proteins
- LI Cadherin
- Protein Type
- Recombinant
- Protein Characteristics
- AA 23-667
-
Origin
- Human
-
Source
- HEK-293 Cells
- Purification tag / Conjugate
- This LI Cadherin protein is labelled with His tag.
- Purpose
- Human CDH17/Cadherin 17 Domain 1-6 Protein
- Sequence
- Gln23-Leu667
- Characteristics
- Recombinant Human CDH17/Cadherin 17 Domain 1-6 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln23-Leu667.
- Purity
- > 95 % as determined by Tris-Bis PAGE
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- Immobilized Human CDH17 Domain 1-6, His Tag at 1_g/ml (100_l/Well) on the plate. Dose response curve for Anti-CDH17 Anitibody, hFc Tag with the EC50 of 7.3ng/ml determined by ELISA. See testing image for detail.
- Top Product
- Discover our top product LI Cadherin Protein
-
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22 μm filtered solution in 20 mM Tris, 150 mM NaCl ( pH 8.0).. Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
-
- Target
- LI Cadherin
- Alternative Name
- CDH17 (LI Cadherin Products)
- Synonyms
- CDH16 Protein, HPT-1 Protein, HPT1 Protein, HPT-1/LI Protein, cb903 Protein, fb65d02 Protein, wu:fb65d02 Protein, cadherin-17 Protein, cadherin 17 Protein, cadherin 17, LI cadherin (liver-intestine) Protein, CDH17 Protein, Cdh17 Protein, cdh17 Protein
- Background
- Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.
- Molecular Weight
- 72.90 kDa. Due to glycosylation, the protein migrates to 90-110 kDa based on Tris-Bis PAGE result.
- UniProt
- Q12864
-