Clusterin Protein (CLU) (AA 22-448) (His tag)
Quick Overview for Clusterin Protein (CLU) (AA 22-448) (His tag) (ABIN7274369)
Target
See all Clusterin (CLU) ProteinsProtein Type
Origin
Source
Purity
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Protein Characteristics
- AA 22-448
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Purification tag / Conjugate
- This Clusterin protein is labelled with His tag.
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Purpose
- Mouse Clusterin Protein
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Sequence
- Glu22-Glu448
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Characteristics
- Recombinant Mouse Clusterin Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Glu22-Glu448.
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Sterility
- 0.22 μm filtered
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Endotoxin Level
- Less than 1EU per μg by the LAL method.
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Clusterin (CLU) (AA 23-449) protein (His tag)
CLU Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Clusterin (CLU) (AA 184-293) protein (His-IF2DI Tag)CLU Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Clusterin (CLU) (AA 402-501) protein (GST tag)CLU Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
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Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
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Storage
- -20 °C,-80 °C
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Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
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Expiry Date
- 12 months
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- Clusterin (CLU)
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Alternative Name
- Clusterin
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Background
- Clusterin (CLU) is a stress-activated, ATP-independent molecular chaperone, normally secreted from cells, that is up-regulated in Alzheimer disease and in many cancers. It plays important roles in protein homeostasis/proteostasis, inhibition of cell death pathways, and modulation of pro-survival signalling and transcriptional networks. Changes in the CLU gene locus are highly associated with Alzheimer disease, and many therapy-resistant cancers over-express CLU.
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Molecular Weight
- 50.4 kDa. Due to autocatalytic cleavage, the protein migrates to 35-40 kDa and 43-50 kDa based on Tris-Bis PAGE result.
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UniProt
- Q06890
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Pathways
- Apoptosis, Negative Regulation of intrinsic apoptotic Signaling
Target
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