CRTAM Protein (AA 18-287) (His tag)
Quick Overview for CRTAM Protein (AA 18-287) (His tag) (ABIN7274415)
Target
See all CRTAM ProteinsProtein Type
Biological Activity
Origin
Source
Purity
-
-
Protein Characteristics
- AA 18-287
-
Purification tag / Conjugate
- This CRTAM protein is labelled with His tag.
-
Purpose
- Canine CRTAM Protein
-
Sequence
- Phe18-Gly287
-
Characteristics
- Recombinant Canine CRTAM Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Phe18-Gly287.
-
Sterility
- 0.22 μm filtered
-
Endotoxin Level
- Less than 1 EU per μg by the LAL method.
-
Biological Activity Comment
- Canine CRTAM on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
-
-
Want other Options for this Protein ?
!Discover Our Predefined Custom Proteins and Custom Protein Services!Your project requires further customization? Contact us and discover our custom protein solutions
-
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 18-287) (Active) protein (hFc Tag)
CRTAM Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 1-393) protein (GST tag)CRTAM Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Cytotoxic and Regulatory T Cell Molecule (CRTAM) protein (Fc Tag)CRTAM Origin: Cynomolgus Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 18-287) protein (His tag)CRTAM Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 17-289) (Active) protein (His tag)CRTAM Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE Active
-
-
Restrictions
- For Research Use only
-
-
-
Format
- Lyophilized
-
Reconstitution
- Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1 mg/mL for 500 μg or 1 mg lyophilized powder. Do not mix by vortex or vigorous shaking.
-
Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
-
Storage
- -20 °C,-80 °C
-
Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3 months after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
-
Expiry Date
- 12 months
-
-
- CRTAM (Cytotoxic and Regulatory T Cell Molecule (CRTAM))
-
Alternative Name
- CRTAM
-
Background
- Class-I Restricted T Cell-Associated Molecule (CRTAM) is a protein that is expressed after T cell activation. The interaction of CRTAM with its ligand, nectin-like 2 (Necl2), is required for the efficient production of IL-17, IL-22, and IFNγ by murine CD4 T cells, and it plays a role in optimal CD8 T and NK cell cytotoxicity. CRTAM promotes the pro-inflammatory cytokine profile, therefore, it may take part in the immunopathology of autoimmune diseases such as diabetes type 1 or colitis.
-
Molecular Weight
- 31.19 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Bis-Tris PAGE result.
-
UniProt
- E2QWY2
-
Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
Target
-
