CRTAM Protein (AA 17-289) (His tag)
Quick Overview for CRTAM Protein (AA 17-289) (His tag) (ABIN7274417)
Target
See all CRTAM ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 17-289
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Purification tag / Conjugate
- This CRTAM protein is labelled with His tag.
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Purpose
- Mouse CRTAM Protein
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Sequence
- Ala17-Gly289
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Characteristics
- Recombinant Mouse CRTAM Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ala17-Gly289.
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Sterility
- 0.22 μm filtered
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Endotoxin Level
- Less than 1 EU per μg by the LAL method.
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Biological Activity Comment
- Mouse CRTAM on Bis-Tris PAGE under reduced condition. The purity is greater than 90%.
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Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 18-287) (Active) protein (hFc Tag)
CRTAM Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 1-393) protein (GST tag)CRTAM Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Cytotoxic and Regulatory T Cell Molecule (CRTAM) protein (Fc Tag)CRTAM Origin: Cynomolgus Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 18-287) protein (His tag)CRTAM Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 18-287) (Active) protein (His tag)CRTAM Origin: Dog Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1 mg/mL for 500 μg or 1 mg lyophilized powder. Do not mix by vortex or vigorous shaking.
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Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
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Storage
- -20 °C,-80 °C
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Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3 months after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
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Expiry Date
- 12 months
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- CRTAM (Cytotoxic and Regulatory T Cell Molecule (CRTAM))
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Alternative Name
- CRTAM
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Background
- Class-I Restricted T Cell-Associated Molecule (CRTAM) is a protein that is expressed after T cell activation. The interaction of CRTAM with its ligand, nectin-like 2 (Necl2), is required for the efficient production of IL-17, IL-22, and IFNγ by murine CD4 T cells, and it plays a role in optimal CD8 T and NK cell cytotoxicity. CRTAM promotes the pro-inflammatory cytokine profile, therefore, it may take part in the immunopathology of autoimmune diseases such as diabetes type 1 or colitis.
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Molecular Weight
- 31.1 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
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UniProt
- Q149L7
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Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
Target
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