EGFRviii Protein (AA 25-378) (FITC,His-Avi Tag)

Catalog No. ABIN7274519

Product Details

Target: EGFRviii (EGFRv3) (EGFR vIII (EGFRv3))

Protein Type: Recombinant

Protein Characteristics: AA 25-378

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This EGFRviii protein is labelled with FITC,His-Avi Tag.

Purpose: FITC-Labeled Human EGFRVIII Protein

Sequence: Leu25-Ser378

Characteristics: Recombinant FITC-Labeled Human EGFRVIII Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Leu25-Ser378.

Purity: > 95 % as determined by Tris-Bis PAGE

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied as 0.22μm filtered solution in PBS ( pH 7.4).

Storage: -80 °C

Storage Comment: Valid for 12 months from date of receipt when stored at -80°C., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: EGFRviii (EGFRv3) (EGFR vIII (EGFRv3))

Alternative Name: EGFRVIII (EGFRv3 Products)

Background: The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand.

Molecular Weight: 41.6 kDa. Due to glycosylation, the protein migrates to 68-80 kDa based on Tris-Bis PAGE result.

NCBI Accession: NP_001333870