EGFRviii Protein (Alexa Fluor 488,His tag)
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- Target See all EGFRviii (EGFRv3) products
- EGFRviii (EGFRv3) (EGFR vIII (EGFRv3))
- Protein Type
- Recombinant
- Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This EGFRviii protein is labelled with Alexa Fluor 488,His tag.
- Purpose
- Alexa Fluor™ 488-Labeled Human EGFRvIII Protein, His TagStar Staining
- Sequence
- Leu 25 - Ser 378
- Characteristics
- Alexa Fluor 488-Labeled Human EGFRvIII, His Tag is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Ser 378 (Accession # NP_001333870.1).
- Purity
- 90 %
- Endotoxin Level
- 1.0 EU per μg
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- Comment
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This protein carries a polyhistidine tag at the C-terminus. (AF488 ,10xHis) The protein has a calculated MW of 53.0 kDa.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Storage
- -20 °C
- Storage Comment
- -20°C, avoid light
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- Target
- EGFRviii (EGFRv3) (EGFR vIII (EGFRv3))
- Alternative Name
- EGFRvIII (EGFRv3 Products)
- Background
- The epidermal growth factor receptor (EGFR, ErbB-1, HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer. The type III EGF deletion mutant receptor (EGFRvIII) is the most common mutation and was first identified in primary human glioblastoma tumors. This tumor-specific antigen is ligand-independent, contains a constitutively active tyrosine kinase domain, and has been shown to be present in a number of human malignancies. EGFRvIII has been selected as a target for CAR-modified T-cell studies in recent years.
- Molecular Weight
- 53.0 kDa
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