FGFR-1 Alpha(IIIc) (AA 22-374) (Active) protein (Biotin,His-Avi Tag)
This Recombinant FGFR-1 Alpha(IIIc) protein is produced in HEK-293 Cells.
Catalog No. ABIN7274634
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Quick Overview for FGFR-1 Alpha(IIIc) (AA 22-374) (Active) protein (Biotin,His-Avi Tag) (ABIN7274634)
Target
FGFR-1 Alpha(IIIc)
Protein Type
Recombinant
Biological Activity
Active
Origin
Human
Source
HEK-293 Cells
Purity
> 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC
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Protein Characteristics
- AA 22-374
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Purification tag / Conjugate
- Biotin,His-Avi Tag
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Purpose
- Biotinylated Human FGFR1 alpha (IIIc) Protein
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Sequence
- Arg22-Glu374
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Characteristics
- Recombinant Biotinylated Human FGFR1 alpha (IIIc) Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Arg22-Glu374.
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Sterility
- 0.22 μm filtered
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Endotoxin Level
- Less than 1 EU per μg by the LAL method.
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Biological Activity Comment
- Immobilized Biotinylated Human FGFR1 alpha (IIIc), His Tag at 1ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-FGFR1 Antibody, hFc Tag with the EC50 of 10.8ng/ml determined by ELISA.,Biotinylated Human FGFR1 alpha (IIIc) -on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.,The purity of Biotinylated-Human FGFR1 alpha (IIIc) is greater than 95% as determined by SEC-HPLC.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1 mg/mL for 500 μg or 1 mg lyophilized powder. Do not mix by vortex or vigorous shaking.
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Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
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Storage
- -20 °C,-80 °C
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Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3 months after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
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Expiry Date
- 12 months
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- FGFR-1 Alpha(IIIc)
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Alternative Name
- FGFR1 alpha (IIIc)
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Background
- Fibroblast growth factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentiation, angiogenesis, wound healing and tumorgenesis. The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding.FGFR1 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system.
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Molecular Weight
- 42 kDa. Due to glycosylation, the protein migrates to 68-80 kDa based on Tris-BisPAGE result.
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UniProt
- P11362
Target
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