Insulin-Like Growth Factor-Binding Protein 3 Receptor (TMEM219) (AA 39-204) (Active) protein (hFc Tag)

Catalog No. ABIN7274861

Recombinant Insulin-Like Growth Factor-Binding Protein 3 Receptor protein expressed in HEK-293 Cells.

Quick Overview for Insulin-Like Growth Factor-Binding Protein 3 Receptor (TMEM219) (AA 39-204) (Active) protein (hFc Tag) (ABIN7274861)

Target: Insulin-Like Growth Factor-Binding Protein 3 Receptor (TMEM219)

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: HEK-293 Cells

Purity: > 95 % as determined by Bis-Tris PAGE

Product Details

Protein Characteristics: AA 39-204

Purification tag / Conjugate: hFc Tag

Purpose: Human IGFBP-3R Protein

Sequence: Ser39-Arg204

Characteristics: Recombinant Human IGFBP-3R Protein is expressed from HEK293 with hFc (IgG1) tag at the C-Terminus.It contains Ser39-Arg204.

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1 EU per μg by the LAL method.

Biological Activity Comment: Human IGFBP-3R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1 mg/mL for 500 μg or 1 mg lyophilized powder. Do not mix by vortex or vigorous shaking.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3 months after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: Insulin-Like Growth Factor-Binding Protein 3 Receptor (TMEM219)

Alternative Name: IGFBP-3R

Background: Insulin-like growth factor-binding protein-3 (IGFBP-3) is a multifunctional protein known for modulating mitogenic and metabolic actions of IGFs as well as exerting a variety of biological actions not involving IGF. IGFBP-3 inhibits airway inflammation and hyper-responsiveness via an IGF-independent mechanism that involves activation of IGFBP-3R signaling and cross-talk with NF-κB signaling. The IGFBP-3/IGFBP-3R system therefore plays a pivotal role in the pathogenesis of asthma and can serve as a newly identified potential therapeutic target for this debilitating disease.

Molecular Weight: 44.5 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.

UniProt: Q86XT9