IgG4 Fc (AA 99-326) (Active) Protein
This Recombinant IgG4 Fc protein is produced in HEK-293 Cells.
Catalog No. ABIN7274868
$137.92
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Quick Overview for IgG4 Fc (AA 99-326) (Active) Protein (ABIN7274868)
Target
IgG4 Fc
Protein Type
Recombinant
Biological Activity
Active
Origin
Human
Source
HEK-293 Cells
Purity
> 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC
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Protein Characteristics
- AA 99-326
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Purpose
- Human IgG4 Fc Protein
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Sequence
- Glu99-Gly326
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Characteristics
- Recombinant Human IgG4 Fc Protein is expressed from HEK293 without tag.It contains Glu99-Gly326.
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Sterility
- 0.22 μm filtered
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Endotoxin Level
- Less than 1 EU per μg by the LAL method.
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Biological Activity Comment
- Human FcRn, His Tag captured on CM5 Chip via Anti-His Antibody can bind Human IgG4 Fc, No Tag with an affinity constant of 1.365 uM as determined in SPR assay (Biacore T200).,Human IgG4 Fc on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.,The purity of Human IgG4 Fc is greater than 95% as determined by SEC-HPLC.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1 mg/mL for 500 μg or 1 mg lyophilized powder. Do not mix by vortex or vigorous shaking.
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Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
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Storage
- -20 °C,-80 °C
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Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3 months after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
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Expiry Date
- 12 months
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- IgG4 Fc
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Background
- It is known as a IgG4-related disease and its differentiation is based on the analysis of IgG4 levels in the affected tissues. The IgG4-related disease is considered to be a generalized pathological process involving a wide spectrum of various disorders that may affect distant organs.
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Molecular Weight
- 25.8 kDa. Due to glycosylation, the protein migrates to 30-35 kDa based on Bis-Tris PAGE result.
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UniProt
- P01861
Target
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