TNFRSF11A Protein (AA 31-214) (Fc Tag)
Quick Overview for TNFRSF11A Protein (AA 31-214) (Fc Tag) (ABIN7275522)
Target
See all TNFRSF11A ProteinsProtein Type
Origin
Source
Purity
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Protein Characteristics
- AA 31-214
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Purification tag / Conjugate
- This TNFRSF11A protein is labelled with Fc Tag.
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Purpose
- Mouse TNFRSF11A/Rank Protein
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Sequence
- Val31-Ser214
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Characteristics
- Recombinant Mouse TNFRSF11A/Rank Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Val31-Ser214.
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Sterility
- 0.22 μm filtered
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Endotoxin Level
- Less than 1EU per μg by the LAL method.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
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Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
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Storage
- -20 °C,-80 °C
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Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
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Expiry Date
- 12 months
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- TNFRSF11A (Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A))
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Alternative Name
- TNFRSF11A
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Background
- TNFRSF11A, also known as receptor activator of NF-κB (RANK), activates several signaling pathways, such as NF-κB, JNK, ERK, p38α, and Akt/PKB. RANK/TNFRSF11A is a novel and frequent target for de novo methylation in gliomas, which affects apoptotic activity and focus formation thereby contributing to the molecular pathogenesis of gliomas.
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Molecular Weight
- 47.0 kDa. Due to glycosylation, the protein migrates to 57-67 kDa based on Tris-Bis PAGE result.
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UniProt
- O35305
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Pathways
- NF-kappaB Signaling
Target
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