Transglutaminase 2 Protein (AA 2-687) (His tag)

Catalog No. ABIN7275723

This Recombinant Transglutaminase 2 protein is produced in Escherichia coli (E. coli).

Quick Overview for Transglutaminase 2 Protein (AA 2-687) (His tag) (ABIN7275723)

Target: Transglutaminase 2 (TGM2) (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 95 % as determined by Bis-Tris PAGE

Product Details

Protein Characteristics: AA 2-687

Purification tag / Conjugate: This Transglutaminase 2 protein is labelled with His tag.

Purpose: Human TGM2 Protein

Sequence: Ala2-Ala687

Characteristics: Recombinant Human TGM2 Protein is expressed from E.coli with His tag at the N-Terminus.It contains Ala2-Ala687.

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1 EU per μg by the LAL method.

Biological Activity Comment: Immobilized Human TGM2, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-TGM2 Antibody, hFc Tag with the EC50 of 6.1ng/ml determined by ELISA.,Human TGM2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied as 0.22μm filtered solution in 20 mM Tris, 500 mM NaCl, 10 % Glycerol ( pH 7.4).

Storage: -80 °C

Storage Comment: Valid for 12 months from date of receipt when stored at -80°C., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: Transglutaminase 2 (TGM2) (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2))

Alternative Name: TGM2

Background: Transglutaminase 2 (TGM2) is a member of the transglutaminase family, and it is reported to be associated with chemoresistance in various types of cancer. TGM2 was demonstrated to affect the chemosensitivity of osteosarcoma cells via regulation of the activation of mitogen-activated protein kinase and AKT serine/threonine kinase pathways.

Molecular Weight: 78.4 kDa same as Bis-Tris PAGE result.

UniProt: P21980

Pathways: Tube Formation, Thromboxane A2 Receptor Signaling