KIT Ligand Protein (KITLG) (AA 26-189)

Catalog No. ABIN7447897

This Recombinant KIT Ligand protein is produced in HEK-293 Cells.

Quick Overview for KIT Ligand Protein (KITLG) (AA 26-189) (ABIN7447897)

Target: KIT Ligand (KITLG)

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: 90,00 %

Product Details

Protein Characteristics: AA 26-189

Purpose: Human SCF / KITLG (26-189) Protein, premium grade

Brand: Premium grade

Sequence: Glu 26 - Ala 189

Characteristics: Human SCF (26-189), premium grade is expressed from human 293 cells (HEK293). It contains AA Glu 26 - Ala 189 (Accession # P21583-1).
Premium grade: This product is produced under rigorous quality control system that incorporates a comprehensive set of tests including sterility and endotoxin tests. Product performance is carefully validated and tested for compatibility for cell culture use or any other applications in the early preclinical stage.

Sterility: Sterile

Endotoxin Level: 0.1 EU per μg

Application Details

Comment:

This protein carries no "tag". The protein has a calculated MW of 18.5 kDa. The protein migrates as 20-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS, pH 7.4

Storage: -20 °C

Storage Comment: -20°C

Target Details

Target: KIT Ligand (KITLG)

Alternative Name: SCF

Background: Synonyms:KITLG,FPH2,KL-1,Kitl,MGF,SCF,SF,SHEP7,KL,Description:Stem Cell Factor is also known as SCF, kit-ligand, KL, steel factor, KITLG, FPH2, KL-1, Kitl, MGF, SCF, SF, or SHEP7, and is a cytokine that binds to the c-Kit receptor (CD117). SCF can exist both as a transmembrane protein and a soluble protein. This cytokine plays an important role in hematopoiesis (formation of blood cells), spermatogenesis, and melanogenesis. The soluble and transmembrane forms of the protein are formed by alternative splicing of the same R transcript.Soluble and transmembrane SCF is produced by fibroblasts and endothelial cells. Soluble SCF has a molecular weight of 18,5 KDa and forms a dimer. SCF plays an important role in the hematopoiesis during embryonic development. Sites where hematopoiesis takes place, such as the fetal liver and bone marrow, all express SCF. During development, the presence of the SCF also plays an important role in the localization of melanocytes, cells that produce melanin and control pigmentation. SCF plays a role in the regulation of HSCs in the stem cell niche in the bone marrow. SCF may be used along with other cytokines to culture HSCs and hematopoietic progenitors. The expansion of these cells ex-vivo (outside the body) would allow advances in bone-marrow transplantation, in which HSCs are transferred to a patient to re-establish blood formation.

Molecular Weight: 18.5 kDa

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway