PRNP Protein (AA 90-230) (Fc Tag)

Catalog No. ABIN7490844

Product Details

Target: PRNP (Prion Protein (PRNP))

Protein Type: Recombinant

Protein Characteristics: AA 90-230

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This PRNP protein is labelled with Fc Tag.

Purpose: Recombinant human PRNP (90-230) protein with C-terminal human Fc tag

Specificity: PRNP (Gly90-Ser230) hFc (Glu99-Ala330)

Characteristics: Extracellular Domain Protein

Purity: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: PRNP (Prion Protein (PRNP))

Alternative Name: PRNP (PRNP Products)

Synonyms: ASCR Protein, AltPrP Protein, CD230 Protein, CJD Protein, GSS Protein, KURU Protein, PRIP Protein, PrP Protein, PrP27-30 Protein, PrP33-35C Protein, PrPc Protein, p27-30 Protein, Prn Protein, Prn-p Protein, prp Protein, cjd Protein, prion Protein, prp(c) Protein, MGC84114 Protein, PRP Protein, PRPC Protein, Prp Protein, SIP Protein, PRNP Protein, AA960666 Protein, AI325101 Protein, PrP Protein, PrPC Protein, PrPSc Protein, Prn-i Protein, Sinc Protein, prP27-30 Protein, prP33-35C Protein, PrP-1 Protein, PrP1 Protein, prnprs1 Protein, stPrP-1 Protein, zgc:123004 Protein, prion protein Protein, prion protein S homeolog Protein, prion protein b Protein, PRNP Protein, Prnp Protein, prnp.S Protein, prnpb Protein

Background: PrP, ASCR, PrP27-30, PrP33-35C, CD230
Description: The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Molecular Weight: predicted molecular mass of 42.2 kDa after removal of the signal peptide. The apparent molecular mass of PRNP(90-230)-hFc is 55-70 kDa due to glycosylation.

UniProt: P04156

Pathways: Transition Metal Ion Homeostasis, Activated T Cell Proliferation