IRF5 Protein (His tag)
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- Target See all IRF5 Proteins
- IRF5 (Interferon Regulatory Factor 5 (IRF5))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This IRF5 protein is labelled with His tag.
- Purpose
- Recombinant Human Interferon Regulatory Factor 5 is produced by our E.coli expression system and the target gene encoding Met1-Gln498 is expressed with a 6His tag at the C-terminus.
- Characteristics
- Extracellular Domain Protein
- Purification
- Affinity purification
- Purity
- Greater than 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product IRF5 Protein
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- Restrictions
- For Research Use only
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- Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, 30 % Glycerol, 1 mM DTT, pH 8.0.
- Storage
- -80 °C
- Storage Comment
- Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- IRF5 (Interferon Regulatory Factor 5 (IRF5))
- Alternative Name
- IRF5 (IRF5 Products)
- Background
- Interferon Regulatory Factor 5 (IRF5) is a member of the IRF family. It contains one IRF tryptophan pentad repeat DNA-binding domain. IRF5 shuttles between the nucleus and the cytoplasm. IRF5 can form homodimer when it is phosphorylated. IRF5 functions as a transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Genetic variations in IRF5 are associated with susceptibility to systemic lupus erythematosus type 10. In addition, the genetic variations wil result in susceptibility to rheumatoid arthritis.
- Molecular Weight
- 57.1 KDa
- UniProt
- Q13568
- Pathways
- TLR Signaling, Autophagy
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