Claudin 4 Protein (CLDN4) (AA 145-157) (Fc Tag)
Quick Overview for Claudin 4 Protein (CLDN4) (AA 145-157) (Fc Tag) (ABIN7491285)
Target
See all Claudin 4 (CLDN4) ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 145-157
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Purification tag / Conjugate
- This Claudin 4 protein is labelled with Fc Tag.
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Purpose
- Recombinant Human CLDN4(145-157) Protein with C-terminal human Fc tag
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Specificity
- CLDN4(Gln145-Lys157) hFc(Glu99-Ala330)
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Characteristics
- Extracellular Domain Protein
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Purification
- Purified from cell culture supernatant by affinity chromatography
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Claudin 4 (CLDN4) (AA 1-210) protein (His tag)
custom-made CLDN4 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Claudin 4 (CLDN4) (AA 1-209) protein (His tag)custom-made CLDN4 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Claudin 4 (CLDN4) protein (DYKDDDDK Tag)CLDN4 Origin: Human Host: HEK-293 Cells Synthetic Nanodisc ELISA, cryo-EM, Imm, PhD, SPR
Claudin 4 (CLDN4) (AA 1-209) protein (GST tag)CLDN4 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
Claudin 4 (CLDN4) (AA 145-157) protein (mFc Tag)CLDN4 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
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Application Notes
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Extracellular Domain Proteins (ECD) can be used as:
- Immunogens for antibody drug development
- Reagents used for CAR-T positive cell monitoring
- Reagents for antibody screening and functional testing
- Reagents for antibody affinity measurement
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Comment
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The protein was produced using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target protein.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please see Certificate of Analysis for specific instructions of reconstitution.
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Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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Expiry Date
- 12 months
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- Claudin 4 (CLDN4)
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Alternative Name
- CLDN4
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Background
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CPE-R,CPER,CPETR,CPETR1,hCPE-R,WBSCR8
The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013] -
Molecular Weight
- predicted molecular mass of 27.6 kDa after removal of the signal peptide. The apparent molecular mass of CLDN4(145-157)-hFc is 25-35 kDa due to glycosylation.
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UniProt
- O14493
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Pathways
- Hepatitis C
Target
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