RHOC Protein (AA 1-189) (Fc Tag)

Catalog No. ABIN7491411

This Recombinant RHOC protein is produced in HEK-293 Cells.

Quick Overview for RHOC Protein (AA 1-189) (Fc Tag) (ABIN7491411)

Target: RHOC (Ras Homolog Gene Family, Member C (RHOC))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Product Details

Protein Characteristics: AA 1-189

Purification tag / Conjugate: This RHOC protein is labelled with Fc Tag.

Purpose: Recombinant Human RHOC(1-189) Protein with C-terminal human Fc tag

Specificity: RHOC (Met1-Gly189) hFc (Glu99-Ala330)

Characteristics: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: RHOC (Ras Homolog Gene Family, Member C (RHOC))

Alternative Name: RhoC

Background: This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Molecular Weight: predicted molecular mass of 47.7 kDa after removal of the signal peptide. The apparent molecular mass of RHOC(1-189)-hFc is 35-55 kDa due to glycosylation.

UniProt: P08134

Pathways: WNT Signaling, Cell-Cell Junction Organization