Quick Overview for MC4R Protein (ABIN7491693)
Target
See all MC4R ProteinsProtein Type
Origin
Source
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Purpose
- Human MC4R full length protein-synthetic nanodisc
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Characteristics
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
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Melanocortin 4 Receptor (MC4R) (AA 1-332) protein (His tag)
custom-made MC4R Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Melanocortin 4 Receptor (MC4R) (AA 1-332) protein (His tag)custom-made MC4R Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Melanocortin 4 Receptor (MC4R) (AA 1-43) protein (Fc Tag)MC4R Origin: Human Host: Mammalian Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Melanocortin 4 Receptor (MC4R) (AA 1-43) protein (GST tag)MC4R Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Melanocortin 4 Receptor (MC4R) protein (Myc-DYKDDDDK Tag)MC4R Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Comment
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Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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Expiry Date
- 12 months
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- MC4R (Melanocortin 4 Receptor (MC4R))
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Alternative Name
- MC4R
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Background
- The protein is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity.
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Molecular Weight
- The human full length MC4R protein has a MW of 36.9 kDa
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UniProt
- P32245
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Pathways
- Hormone Transport, cAMP Metabolic Process, Feeding Behaviour
Target
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