LILRB1 Protein (Biotin,His-Avi Tag)
Quick Overview for LILRB1 Protein (Biotin,His-Avi Tag) (ABIN7482363)
Target
See all LILRB1 ProteinsProtein Type
Origin
Source
Purity
Grade
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Purification tag / Conjugate
- This LILRB1 protein is labelled with Biotin,His-Avi Tag.
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Purpose
- Biotinylated Human LILRB1 / CD85j / ILT2 Protein, His,Avitag™ (MALS verified)
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Sequence
- Ala 23 - Thr 431
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Characteristics
- Biotinylated Human LILRB1 Protein, His,Avitag is expressed from human 293 cells (HEK293). It contains AA Ala 23 - Thr 431 (Accession # Q8NHL6-1).
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Endotoxin Level
- 1.0 EU per μg
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Comment
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This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). (Biotin,10xHis , Avi) The protein has a calculated MW of 48.2 kDa. The protein migrates as 52-64 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- PBS, pH 7.4
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Storage
- -20 °C
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Storage Comment
- -20°C
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- LILRB1 (Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 1 (LILRB1))
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Alternative Name
- LILRB1
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Background
- This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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Molecular Weight
- 48.2 kDa
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Pathways
- Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
Target
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