IL-23 alpha & IL-12 beta Protein
Quick Overview for IL-23 alpha & IL-12 beta Protein (ABIN7488786)
Target
Protein Type
Origin
Source
Purity
Grade
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Purpose
- Human IL-23 alpha & IL-12 beta Heterodimer Protein, premium grade
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Sequence
- Ile 23 - Ser 328 (IL-12B) & Arg 20 - Pro 189 (IL-23A)
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Characteristics
- Human IL-23A&IL-12B Heterodimer Protein, premium grade is expressed from human 293 cells (HEK293). It contains AA Ile 23 - Ser 328 (IL-12B) & Arg 20 - Pro 189 (IL-23A) (Accession # P29460-1 (IL-12B) & Q9NPF7-1 (IL-23A).
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Endotoxin Level
- 0.1 EU per μg
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IL-23 alpha & IL-12 beta (AA 20-189) (Active) protein (Biotin,His-Avi Tag)
Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
IL-23 alpha & IL-12 beta (AA 20-189) (Active) protein (His-Avi Tag)Origin: Human, Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
IL-23 alpha & IL-12 beta (AA 22-196) (Active) protein (His tag)Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
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Comment
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This protein carries no "tag". () The protein has a calculated MW of 55.0 kDa. The protein migrates as 60-65 kDa and 116 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- PBS, pH 7.4
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Storage
- -20 °C
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Storage Comment
- -20°C
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- IL-23 alpha & IL-12 beta
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Background
- Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
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Molecular Weight
- 55.0 kDa
Target
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