IL-31 Protein
Quick Overview for IL-31 Protein (ABIN7488784)
Target
See all IL-31 (IL31) ProteinsProtein Type
Origin
Source
Purity
Grade
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Purpose
- Human IL-31 Protein, premium grade
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Sequence
- Ser 24 - Thr 164
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Characteristics
- Human IL-31 Protein, premium grade is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Thr 164 (Accession # Q6EBC2-1).
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Endotoxin Level
- 0.1 EU per μg
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Interleukin 31 (IL31) (AA 27-163) protein (His tag)
IL31 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 31 (IL31) (AA 24-163) protein (His tag)IL31 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Interleukin 31 (IL31) (AA 24-164) protein (Fc Tag)IL31 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 31 (IL31) (AA 24-159) protein (His tag)IL31 Origin: Dog Host: Baculovirus infected Insect Cells Recombinant > 95% by SDS-PAGE SDS
Interleukin 31 (IL31) proteinIL31 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant 97,00% SDS
Interleukin 31 (IL31) (AA 24-164) (Active) protein (His tag)IL31 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Interleukin 31 (IL31) proteinIL31 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant 97,00% SDS
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Comment
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This protein carries no "tag". () The protein has a calculated MW of 15.8 kDa. The protein migrates as 18-20 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- PBS, pH 7.4
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Storage
- -20 °C
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Storage Comment
- -20°C
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- IL-31 (IL31) (Interleukin 31 (IL31))
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Alternative Name
- IL-31
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Background
- IL-31 is an inflammatory cytokine that helps trigger cell-mediated immunity against pathogens. Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. It has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis. May function in skin immunity. IL-31 is produced by a variety of cells, namely type 2 helper (TH2) T-cells. IL-31 sends signals through a receptor complex made of IL-31RA and oncostatin M receptor β (OSMRβ) expressed in immune and epithelial cells. These signals activate three pathways: ERK1/2 MAP kinase, PI3K/AKT, and JAK1/2 signaling pathways.
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Molecular Weight
- 15.8 kDa
Target
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