Mesothelin Protein (MSLN) (Fc Tag)
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- Target See all Mesothelin (MSLN) Proteins
- Mesothelin (MSLN)
- Protein Type
- Recombinant
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Mesothelin protein is labelled with Fc Tag.
- Purpose
- Mouse Mesothelin / MSLN Protein, Fc Tag
- Sequence
- Asp 298 - Ser 600
- Characteristics
- Mouse Mesothelin Protein, Fc Tag is expressed from human 293 cells (HEK293). It contains AA Asp 298 - Ser 600 (Accession # Q61468-1).
- Purity
- 90 %
- Endotoxin Level
- 1.0 EU per μg
- Top Product
- Discover our top product MSLN Protein
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- Comment
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This protein carries a human IgG1 Fc tag at the C-terminus. (Fc) The protein has a calculated MW of 60.6 kDa. The protein migrates as 67-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH 7.5
- Storage
- -20 °C
- Storage Comment
- -20°C
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- Target
- Mesothelin (MSLN)
- Alternative Name
- Mesothelin (MSLN Products)
- Background
- Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.
- Molecular Weight
- 60.6 kDa
- Pathways
- EGFR Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process
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