FLNC Protein (AA 2519-2725) (His tag)

Catalog No. ABIN7505105

This Recombinant FLNC protein is expressed in Escherichia coli (E. coli).

Quick Overview for FLNC Protein (AA 2519-2725) (His tag) (ABIN7505105)

Target: FLNC (Filamin C, gamma (FLNC))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Protein Characteristics: AA 2519-2725

Purification tag / Conjugate: This FLNC protein is labelled with His tag.

Sequence: Thr 2519-Pro 2725

Characteristics: A DNA sequence encoding the Human FLNC protein (Q14315) (Thr 2519-Pro 2725) was expressed with a N-His tag.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: FLNC (Filamin C, gamma (FLNC))

Alternative Name: FLNC

Background:

Abbreviation: FLNC

Target Synonym: Filamin C ,FIlamin 2,Filamin C,FLN2,FLNC,ABPL,FLN2

Background: FLNC is a muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z-disks in muscle cells. Defects in FLNC are the cause of autosomal dominant filaminopathy. Myofibrillar myopathy (MFM) is a neuromuscular disorder, usually with an adult onset, characterized by focal myofibrillar destruction and pathological cytoplasmic protein aggregations. Autosomal dominant filaminopathy is a form of MFM characterized by morphological features of MFM and clinical features of a limb-girdle myopathy. A heterozygous nonsense mutation which segregates with the disease, has been identified in the FLNC gene.

Molecular Weight:

Calculated MW: 22.66 kDa

Observed MW: 28 kDa

UniProt: Q14315