MAPK12 Protein (AA 101-367) (His tag)
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- Target See all MAPK12 Proteins
- MAPK12 (Mitogen-Activated Protein Kinase 12 (MAPK12))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 101-367
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This MAPK12 protein is labelled with His tag.
- Sequence
- Asp 101-Leu 367
- Characteristics
- A DNA sequence encoding the Human MAPK12 protein (P53778) (Asp 101-Leu 367) was expressed with a N-His&C-His tag.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product MAPK12 Protein
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Mitogen-Activated Protein Kinase 12 (MAPK12) (AA 1-367) protein (His tag)
custom-made MAPK12 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Mitogen-Activated Protein Kinase 12 (MAPK12) (AA 1-367) protein (His tag)custom-made MAPK12 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Mitogen-Activated Protein Kinase 12 (MAPK12) (AA 1-367) protein (His tag)MAPK12 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Mitogen-Activated Protein Kinase 12 (MAPK12) (AA 1-367) protein (GST tag)MAPK12 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA, KAA
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- MAPK12 (Mitogen-Activated Protein Kinase 12 (MAPK12))
- Alternative Name
- MAPK12 (MAPK12 Products)
- Background
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Abbreviation: MAPK12
Target Synonym: ERK-6;ERK3;ERK6;MAPK12;P38GAMMA;PRKM12;SAPK-3;SAPK3;P38-gamma
Background: ERK3; also known as MAPK12 and p38-gamma; belongs to the protein kinase superfamily; CMGC Ser/Thr protein kinase family and MAP kinase subfamily. ERK3 is highly expressed in skeletal muscle and heart. ERK3 is a serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly; p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK12 is required for the normal kinetochore localization of PLK1; prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.
- Molecular Weight
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Calculated MW: 29.26 kDa
Observed MW: 40 kDa
- UniProt
- P53778
- Pathways
- MAPK Signaling, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Hepatitis C, BCR Signaling, S100 Proteins
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